The use of profiling in personalized therapy for people with autism spectrum disorder (ASD) is the main topic of this paper. It provides an innovative approach aimed at improving the efficacy and accessibility of therapeutic treatments. This paper underlines how important it is to customize therapies to each autistic person's particular requirements and traits. We present profiling as a unique technique integrated into a Virtual Reality (VR)-based system architecture to achieve so. We describe the architecture of this crucial element because it marks a significant development in the effort to provide therapies for people with ASD that are more effective and tailored to their unique needs. It offers a way to use profiling data insights to improve therapeutic outcomes in the VR environment. In doing so, we aim to contribute meaningfully to improving the quality of life and well-being of individuals with ASD.