One of the primary goals of Human-Computer Interaction (HCI) in game design has been the close coupling of players with the digital game system and an increasingly popular approach towards this is Brain-Computer Interaction (BCI). Recent improvements made to electroencephalogram-based (EEG) BCI technology have made it more widely available to researchers, more accessible to target end-users, and more viable for gameplay. However, the research has been limited to one side of serious games—the experiential and simulated environments—there has been little research into gameplay mechanics driven serious games. In this paper, we explore potential avenues for BCI-driven game and serious games gameplay design and development, as well as examining potential issues, conflicts and shortcomings that might arise from utilising BCI. This work informs our ongoing research and development of serious games utilising BCI-driven gameplay and can generalise to the development of other BCI-based games and serious games.