Challenges of the fourth industrial revolution such as shorter product life cycles and increasing product variance require the continuous use of digital technologies in production. Only through these solutions the use of adaptable systems is possible. In this context, the Digital Twin is of crucial importance. The Digital Twin is represented across multiple sectors to meet the technological change. In manufacturing companies its areas of application are versatile. The usage can range from production planning and production monitoring to production optimization. In order to be able to use the advantages of the Digital Twin in the mentioned areas, a targeted data aggregation is necessary. In this paper a cross-application workflow for the efficient planning and usage of Digital Twins is presented. The workflow covers the whole process from the goal and requirement definition up to the implementation and usage of the technology. Particular attention is paid to the aggregation and usage of data in Digital Twins. The developed workflow is evaluated based on an adaptable assembly system.