Porous structures are now recognized as a viable approach to regenerating fractured bone in biomedical applications. The goal of this study is to evaluate the stress distribution patterns in various unit cell designs, comprising variation in porosity ranging from approximately 65–85%. Further, a biocompatible liquid resin has been considered for numerical (FEA) and experimental analysis, and manufacturing scaffolds using the Stereolithography Apparatus (SLA) process. A compression test was performed on all the four designs to validate the load-bearing capacity and compressive strength of the scaffolds. In these findings, the square pyramid and octagonal truss scaffolds showed lower compressive stress values as compared to FCC and BCC designs as strut diameter increased. Moreover, the load-bearing capacity of square pyramid and octagonal truss scaffold was found higher with P3 models. Employing optimal scaffold structures in the field of tissue engineering can help improve the dependability of bone regeneration.