In this chapter, strategies for the introduction and study of CRISPR-Cas systems and their use as a genomic editing tool will be discussed. Lessons covering the natural role of CRISPR systems in bacteria, the molecular mechanisms, potential applications of the knowledge, and ethical considerations of genome editing are suggested here. An opportunity to expose students to how discoveries are made, shared, and expanded by others is presented by the whirlwind adoption of CRISPR techniques across the scientific community. This chapter provides suggestions on lessons that can stand alone or provide the introduction and background that build expertise and lead up to hands-on wet-bench activities or research projects. Suggested approaches for learners from grade 9 through undergraduate senior level coursework will be offered. Scaffolding knowledge and providing multiple opportunities for interacting with material deepens understanding and helps students retain their learning over time. Course instructors can select activities suitable for the level and expertise of their students and the availability of time and resources to dedicate to the study of these naturally occurring systems that provide a powerful method to edit DNA.