This chapter presents a narrative that explores the conceptual development of SPIRO, a spiritually intelligent virtual assistant. The chapter is set within a tech lab where specialists from diverse fields—spirituality, neuroscience, and AI programming—collaborate to create SPIRO. It delves into the challenges encountered during the construction process and evaluates SPIRO’s potential applications in real-world scenarios. Additionally, the chapter discusses the contrast between traditional perspectives on spirituality and the computational approach offered by SPIRO.