Part of the outcomes of the Berlin Conference of 1884/85 was the idea of effective occupation of territories in Africa by the colonialists. The essence was to regulate if not completely avert perennial conflicts and contentions among European powers and then legitimize the imperial rulers’ claims over territories in Africa. This chapter argues that inconsiderately delineated borders and imposition of the resultant territories on Africa underlie the post-colonial border contestations, conflicts and socio-economic underdevelopment in Africa. The chapter concludes that the recurring intra-state border crises, economic failures and many unresolved border-related issues constituting political uncertainties in Africa are linked to the colonial border imprints on the continent.