A significant difficulty in a resource-constrained setting is keeping an optimal sense of balance among safety and other presentation parameters such as memorial need, energy requirement and throughput. In its most recent study on lightweight cryptography, the National Institute of Standards and Technology (NIST) recommended symmetric cyphers for devices with little resources. This work presents statistical security studies of six modern stream ciphers: Espresso, Grain v1, Sprout, Fruit, Plantlet, and Lizard. The analyses were conducted using the following tests: avalanche, randomness, structure, and autocorrelation. After porting the improved code to a microcontroller in low-cost, that is the ATmega 328P, they have also conducted a thorough performance study of these ciphers. A device’s suitability for use in an IoT-based network is a deciding factor in its selection. According to statistical security, performance measurements, and comparative analysis, the chosen ciphers are good choices for situations with limited resources.