Kinesiophobia, known as the fear of movement, is a problem that affects general population and is more common in individuals with chronic pain but also in those without chronic pain. The development of kinesiophobia is influenced by a combination of biological, psychological, and sociocultural factors linked to pain. Therefore, kinesiophobia is in close relationship with many factors that make up the biopsychosocial model (disability, loss of function, psychological problems, etc.). Migraine is one of the primary headache disorders characterized by moderate or severe, often unilateral, throbbing attacks lasting 4–72 h. Kinesiophobia is quite common in individuals with migraine. Some studies have emphasized the need to consider kinesiophobia in management of migraine. In this chapter, pain, clinical features of kinesiophobia, biopsychosocial dimension, and migraine are explained comprehensively. Additionally, kinesiophobia and its features in migraine will be discussed.