Acromegaly is a chronic condition that typically arises from a pituitary adenoma that secretes excessive growth hormone, leading to elevated IGF-1 levels and various associated health issues. Mood disruptions may occur due to hormonal shifts and accompanying complications. The most frequently encountered mood disturbances in acromegaly are depression and anxiety. Nevertheless, acromegaly also causes mental changes beyond those mentioned, including personality alterations, cognitive impairments, and disrupted quality of life. There is conflicting data on the factors linked to acromegaly that contribute to these conditions. Over time, new studies are revealing new mechanisms. Irrespective of the related factors and potential underlying mechanisms, it is vital for clinicians to be mindful of the potential for cognitive and psychological disorders in this patient demographic and to approach them with this understanding. The key to achieving this is by increasing awareness among the clinicians who handle this disease. A crucial measure in addressing mood disorders associated with acromegaly is implementing a comprehensive and multidisciplinary approach.