Taking a complex high-rise integrated building as an example, this study investigates the surface wind pressure and wind-induced vibration of the outer curtain walls of high-rise buildings in the atmospheric boundary layer turbulent flow field. Extreme wind speeds in all directions for a 50-year return period were estimated based on local meteorological data. A comparison was made of the wind pressure distribution between two high-rise buildings within the integrated structure. The research focused on the differences in wind pressure distribution between the external curtain walls of the building and the facade curtain walls subjected to wind pressure on both sides of the building’s top, as well as the variations in these pressure differences at different wind directions. Using the independent storm method, the maximum and minimum wind pressures in all directions on the surfaces of the two high-rise buildings were calculated. The wind-induced vibration response of the roof curtain wall structure was studied, along with the maximum and minimum vibration values and time history of typical nodes on the facade curtain wall in the flow field. The results indicate that there are differences in the average wind pressure and extreme wind pressure distribution between the building’s surface curtain walls and the roof facade curtain walls. Wind direction has a significant impact on the wind pressure on the curtain walls, with the maximum positive pressure appearing in the area of the roof facade curtain wall and the maximum negative pressure occurring in the region near the edges of the building where flow separation is severe. The displacement maximum and minimum values of typical nodes at the top of the facade curtain wall are highly correlated, with a large variance in the forces at the bottom nodes. Design considerations should focus on extreme axial force values and the effects of fatigue failure.