The Smart Attica European Digital Innovation Hub constitutes a driver of innovation with Artificial Intelligence (AI) in Greece by bridging the adoption gap encountered by businesses and public organisations in the country. Treating AI as a cross-sector (horizontal) enabler for a wide range of state-of-the-art services, this paper explores the hub’s value proposition and emphasises the key success factors for ensuring the sustainability of AI adoption efforts. Moreover, the paper introduces a novel holistic approach to the design of AI-powered innovation projects, aiming to enhance impact and cost efficiency. Each such project involves multiple service providers and targets a wide range of beneficiaries. The initial results of this approach are showcased through the hub’s initiative to improve resilience in the face of natural disasters by combining the mobilisation of organisations and society as a whole with technological providers, as a response to recent crises experienced in the country. This established a methodology which is now adopted by the Greek State.