Civilizations have developed in part as a result of human interaction with the changing climatic conditions of the Mediterranean. The purpose of this research is to understand the showcase new insights into the environmental characteristics of the Mediterranean effects of urban elements and to develop the interior architectural layouts on natural conditions consisting of global Mediterranean cities based on the established criteria. This study emphasizes the importance of interior architectural and urban features. Finally, in order to achieve these goals, the following methodology was developed to establish basic principles for producing interior architectural layouts in natural conditions and urban styles in a Mediterranean climate that should be considered when taking into account environmental aspects and future development.