Robotic-assisted inguinal lymphadenectomy (RAIL) was developed for the surgical staging of the inguinal region for squamous cell carcinoma of the penis in the clinically node negative setting, although this technique can be applied to any genital or lower extremity malignancy that has drainage to the inguinal lymph nodes (vulvar carcinoma, melanoma). This technique has been developed to minimize the morbidity associated with the standard open approach, which includes both infectious complications and lymphedema. Despite the minimally invasive approach, standard oncologic principles are maintained, including adherence to the dissection limits and complete removal of lymph nodes within the dissection template.