Indications for robot-assisted radical cystectomy are identical to those of the open approach and the goal is the surgical cure of disease. However, the level of difficulty must be balanced with the surgeon’s comfort and experience, and one must always be prepared for open conversion. A growing body of literature suggests partial cystectomy may represent a viable alternative; however, appropriate patient selection is of paramount importance. Traditional indications include a solitary tumor in a favorable location and the absence of carcinoma in situ. We review our stepwise approach to surgical management of invasive bladder cancer.