The geometry of PEMFC’s flow channels plays a crucial role in influencing overall fuel cell performance, specifically impacting water and humidity regulation, as well as temperature and pressure distribution. Therefore, the main objective of this study is to examine the impact of the combination of different shapes of channels contained in the bipolar plate on the performance of PEMFCs. To achieve this goal, a CFD model of a PEMFC with 25 flow channels, combining serpentine, parallel vertical, and parallel horizontal forms in a three-dimensional, isothermal, steady-state configuration, was developed. A parallel design was used to validate the model with experimental results. The study examisnes parameters such as current density, power density, temperature and pressure profiles at the cathode for different voltages. As a result, using the proposed mixed geometry, an improvement of 20% in the cell performance in terms of power density was observed, compared to the parallel geometry. Moreover, the results obtained have contributed to the understanding of the different phenomena that affect the performance of PEMFCs and help in the optimization of fuel cell technologies.