The design of the layout of logistics spaces represents a fundamental step for the organization and rationalization of industrial production procedures according to an approach that also places sustainability and resilience at the centre of interests within the context of a human-centric approach of the so-called Industry 5.0. The optimization of warehouse flows is strictly connected to the optimal use of space, necessary to guarantee the reduction of operational phases, ease of access and control, and the best efficiency and usability of the spaces. The research work presented in this article aims to define a generally applicable methodology for the design and adaptation of industrial plants, with particular reference to systems intended for warehouse logistics processes. The design guidelines that we want to define will integrate the spatial needs related to practice and business activity with the new research directions that look at digital innovation of companies and energy efficiency. Central to these assumptions is the definition of the structure of the layouts which can determine different performances for the same activities, as they transversally influence multiple aspects such as the health and well-being of workers, the management of spaces, times, energy consumption. The topics covered are the result of an initial research activity carried out at the Solis GreenLog S.r.l. logistics centre, a hub of the Solis S.p.A. group, an integrated temperature-controlled transit point that offers spaces and services for storage, processing, handling and distribution of the goods.