Direct potable reuse (DPR) has emerged as a promising and practical solution to address the challenges of water scarcity (e.g., climate dependency, limited space availability, water waste, and financial constraints) by treating wastewater to meet stringent drinking water quality standards given its potential to reduce water age within the distribution network, enhance water quality, and yield energy savings. Despite the potential benefits, the presence of emerging contaminants in treated wastewater has raised concerns among researchers and policymakers due to their unknown long-term toxicological risks, necessitating continuous research and rigorous monitoring to ensure the safety and sustainability of DPR initiatives. In the present work, ten emerging contaminants were assessed at a pilot-scale treatment plant in the city of Campinas, Brazil, previously selected based on consumption and previous monitoring data. The pilot-scale plant allowed for the evaluation of various treatment configurations, ultimately selecting reverse osmosis + photoperoxidation (UV/H2O2) + activated carbon as the most effective scheme for DPR. The effluent from the pilot plant met the guidelines for potable water set by Brazilian regulations. Among the monitored emerging contaminants, albendazole, carbamazepine, hydrochlorothiazide, sulfamethoxazole, and sucralose were identified as marker compounds for monitoring purposes, as they were detectable in both the influent and effluent of the pilot plant. The findings of this research contribute to the development of robust strategies for monitoring and mitigating the risks associated with emerging contaminants in DPR, ensuring the production of safe and sustainable drinking water sources.