Children and adults with cerebral palsy (CP) are at risk for developing low bone quality and low-impact fractures. Important risk factors compromising bone health in this group are immobility, malnutrition, low body weight, sex steroid deficiency, and medication use (e.g., antiepileptic drugs). Dual-energy X-ray absorptiometry is most commonly used as a diagnostic method for assessing bone quality. Supplementation of vitamin D and calcium and promoting weight-bearing activity are preventive measures that require attention in the care for children and adults with CP. Bisphosphonate therapy may be used to improve bone density in case of multiple or fragility fractures. The chapter reviews all these fields.