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We report high-frequency capacitance measurements and simulations of human red blood cells by a nanoelectrode array imager with submicron spatial resolution. The measurements are compared to numerical finite element method (FEM) simulations within the Poisson-Nernst-Plack modeling framework carried out with a commercial multiphysics platform (COMSOL). Insights on the shape, cartesian position and tilting of the cells on the array are discussed. Two sets of measurements are compared in terms of cell diameter to evaluate the effect of centrifugation on the samples.

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Electrical Characterization of Red Blood Cells with a Nanoelectrode Array Sensor

  • 会议论文

  • 发表日期：

    2025年

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  • Mariano José Guillén,
  • Jacopo Nicolini,
  • Daniele Goldoni,
  • Rossana Madrid,
  • Luca Selmi

摘要

We report high-frequency capacitance measurements and simulations of human red blood cells by a nanoelectrode array imager with submicron spatial resolution. The measurements are compared to numerical finite element method (FEM) simulations within the Poisson-Nernst-Plack modeling framework carried out with a commercial multiphysics platform (COMSOL). Insights on the shape, cartesian position and tilting of the cells on the array are discussed. Two sets of measurements are compared in terms of cell diameter to evaluate the effect of centrifugation on the samples.