The continuous challenge of a competitive market in the manufacturing sector leads companies to improve their productive capabilities. The overall equipment effectiveness (OEE) metric comprises availability, performance, and quality factors. We maintain that the influence of these factors in calculating the OEE in the work dynamics must be considered to identify the management of the production system. Examples of virtual simulations of a line of operation are provided. These factors are modified to compare them with a general model and observe the daily effect in work centers. The result offered by the elaborate simulation helps in understanding the correct implementation of the OEE calculation methodology.