Ascaris is the most common helminth infection in the world, leading to significant global morbidity. Despite the high burden of disease globally, ascariasis remains widely understudied and underfunded leading to a large knowledge gap in basic biological processes. “Omic” technological advancements have significantly accelerated our comprehension of the biological underpinnings of numerous diseases of profound human impact. But adoption of these technologies in Ascaris research has been limited. Moving forward, application of omic technology could provide the first steps to addressing critical knowledge gaps in Ascaris research. Genomic techniques have provided unique insights into the epidemiology and evolution of ascariasis across the world. The application of cutting-edge omic technology in proteomics, metabolomics, lipidomics, and microbiome studies has quickly provided insights into essential Ascaris biological pathways. Detailed characterization of Ascaris biology is a key step in the development of novel interventions including vaccines that are desperately needed to prevent Ascaris-induced morbidity and essential for global elimination efforts.