One of the major concerns of every national government is to achieve the effectiveness of the healthcare system and understanding the efficiency of a system in terms of patient satisfaction. Currently, quality of care is the main driver of patient satisfaction, and their relationship has been widely studied in recent years mainly due to the COVID-19 pandemic. The main objective of this work is to demonstrate the relationship between quality and satisfaction in the case of Spain and to determine which quality indicators in healthcare affect patient satisfaction. The data analyzed correspond to the 17 regions of Spain from 2007 to 2019. The methodology used is based on dynamic panel data with a two-step generalized method of moments applied in the regression models. The results show that hospital mortality is the only quality variable affecting patient satisfaction in a negative way. The main contribution of the work is to empirically test the relationship between these two variables in the case of Spain by taking into account the differences between regions. For further research, other quality measures and satisfaction indices should be implemented in order to complete the recent work.