The purpose of this chapter is to describe the West African Marketplace with a focus on the marketplaces in the southern belt of Ghana. For this paper, the first author visited four regional markets (Makola Market in Accra, Kejetia in Kumasi, Kotokoraba in Cape Coast, and Koforidua Market in the Eastern Region) in the southern belt of the country, gathering some qualitative data about all four marketplaces. The description will include characteristics such as location, layout and days of operation, attributes, as well as regulations and governance. After visiting all four markets, we learned that the marketplaces shared a few similarities—such as strategic location in the town and city centers, the provision of diverse products, cultural significance, and economic activities, and the governance of the marketplaces with the help of the Market Queens. Some of the differences include hours of operation, specific products sold at some markets, the way each market is built and organized, and the governance by either Metropolitan or Municipal Assemblies. While many papers have been written about some marketplaces in Ghana, mainly (Makola and Kejetia), to our knowledge, none have been written in a way that offers a detailed description of all four marketplaces in the Ghanaian southern belt.