Interprofessional collaboration requires the development and maintenance of multiple relationships: with other healthcare providers, supervisors, as well as patients and their families who need to be considered as team members. This chapter documents two distinct orientations to the relationships essential for collaboration: a task orientation and a relationship orientation. A task orientation concentrates on how collegial relationships enable collaborative work to get done more efficiently and effectively, whereas a relationship orientation focuses on how members of interprofessional teams build and consolidate positive interpersonal relationships in the context of their collaboration. The chapter analyzes how role (mis)understanding and lack of trust generate relational challenges in the context of interprofessional collaboration before turning to communicative practices that underpin the creation of compassionate teams, organizations, and workplaces.