The industrial revolution has exacerbated climate change on Earth, mostly due to variables such as rising ambient temperatures, increased levels of greenhouse gases in the atmosphere, and the presence of environmental contaminants. To address this issue, it is imperative to promptly embrace sustainable alternatives. Plasterboard technology presents a viable option for promoting sustainable development, given that about 70% of India’s future building stock remains unconstructed by 2030. Plasterboard technology has had a substantial surge in popularity in Western countries in the last several decades. However, in India, the use of this energy-efficient material remains limited owing to a lack of understanding. This research used the eQUEST simulation tool to analyze the energy usage of a hospitality complex across four distinct climate zones in India. Plasterboards not only save energy consumption but also facilitate the efficient execution of the energy conservation building codes (ECBC). The conventional construction material, namely, burned clay brick with a combined thickness of 280 mm (25 mm (plaster) + 230 mm (FCB) + 25 mm (plaster)), has a thermal transmittance of 2.11 W/m2·K, which is somewhat higher than the specified value in the codes. The thermal transmittance of AAC blocks with the same thickness and layer composition is 0.67 W/m2·K. In contrast, the thermal transmittance of plasterboards with a total thickness of 157 mm is 0.37 W/m2·K, which is below the required value of 0.40 W/m2·K specified in the regulations.