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3D printing, or additive manufacturing, is a revolutionary technology that enables the layer-by-layer fabrication of precise and customizable structures, transforming drug delivery systems. Integrating 3D printing with nanotechnology has unlocked the potential to overcome critical challenges associated with conventional drug delivery, especially for phytochemicals, which are often hindered by poor solubility, rapid degradation, and low bioavailability. Nanocarriers, such as liposomes, polymeric nanoparticles, and phytosomes, protect these sensitive plant-derived compounds, enhance their bioavailability, and enable targeted and sustained release. The ability of 3D printing to incorporate nanocarriers into highly structured delivery systems has facilitated significant advancements, including multi-drug delivery systems, stimuli-responsive mechanisms, and personalized medicine applications. For instance, stimuli-responsive 3D-printed scaffolds can release plant-based therapeutics like tannic acid in response to pH changes in tumor environments. Personalized implants, tailored using patient-specific data, can deliver phytochemicals such as resveratrol or quercetin at optimized rates, enhancing therapeutic outcomes while minimizing systemic side effects. Emerging technologies, including multi-material and 4D printing, coupled with nanoscale precision techniques like two-photon polymerization, are poised to advance the field further. These innovations allow for dynamic, site-specific drug delivery systems capable of addressing complex medical conditions such as cancer, cardiovascular disorders, and inflammatory diseases. However, challenges remain, including scalability, material limitations, and regulatory hurdles. Addressing these through sustainable materials, advanced AI-driven design optimization, and evolving regulatory frameworks will ensure the widespread adoption of 3D-printed nanocarriers. This paradigm shift promises safer, more effective, and highly customizable drug delivery systems, particularly for plant-based therapeutics, paving the way for transformative advancements in personalized and precision medicine.

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Printed Nanocarriers: Advancing Drug Delivery Through 3D Printing

  • 动态工具书词条

  • 发表日期：

    2026年

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  • Nilkamal Waghmare,
  • Aditya Ghuge,
  • Mohit Vij,
  • Neha Dand

摘要

3D printing, or additive manufacturing, is a revolutionary technology that enables the layer-by-layer fabrication of precise and customizable structures, transforming drug delivery systems. Integrating 3D printing with nanotechnology has unlocked the potential to overcome critical challenges associated with conventional drug delivery, especially for phytochemicals, which are often hindered by poor solubility, rapid degradation, and low bioavailability. Nanocarriers, such as liposomes, polymeric nanoparticles, and phytosomes, protect these sensitive plant-derived compounds, enhance their bioavailability, and enable targeted and sustained release. The ability of 3D printing to incorporate nanocarriers into highly structured delivery systems has facilitated significant advancements, including multi-drug delivery systems, stimuli-responsive mechanisms, and personalized medicine applications. For instance, stimuli-responsive 3D-printed scaffolds can release plant-based therapeutics like tannic acid in response to pH changes in tumor environments. Personalized implants, tailored using patient-specific data, can deliver phytochemicals such as resveratrol or quercetin at optimized rates, enhancing therapeutic outcomes while minimizing systemic side effects. Emerging technologies, including multi-material and 4D printing, coupled with nanoscale precision techniques like two-photon polymerization, are poised to advance the field further. These innovations allow for dynamic, site-specific drug delivery systems capable of addressing complex medical conditions such as cancer, cardiovascular disorders, and inflammatory diseases. However, challenges remain, including scalability, material limitations, and regulatory hurdles. Addressing these through sustainable materials, advanced AI-driven design optimization, and evolving regulatory frameworks will ensure the widespread adoption of 3D-printed nanocarriers. This paradigm shift promises safer, more effective, and highly customizable drug delivery systems, particularly for plant-based therapeutics, paving the way for transformative advancements in personalized and precision medicine.