This chapter is devoted to presenting vanadium redox flow battery technology and its integration in multi-energy systems. As starting point, the concept, characteristics and advantages of this type of electrochemical energy system are presented, highlighting the main typologies that currently exist and are used for large scale energy storage purposes. The most important challenges related to control and monitoring are described, presenting the most relevant theoretical and application-based contributions, summarizing a state of the art. A case study is presented in which a vanadium redox flow battery is used in a microgrid to analyze its performance and the role that this type of system can play in multi-energy systems. The last part of this chapter is dedicated to discussing the integration of the redox flow battery device within the paradigm of multi-energy systems, presenting the main benefits, advantages, drawbacks and resources required to implement the proposed solutions.