This chapter has conducted the design and performance analysis of an assisted solar heating, ventilation, and air conditioning (HVAC) system using thermoelectric devices (TEC) analyzing weather data of Izmir, Turkey. During 1 year, the system was studied at Solar Energy Institute, Turkey. It was based on the system design under the premise to reduce the energy consumption in a building of an assisted solar HVAC system using thermoelectric devices for heating and cooling a room. The results obtained with thermoelectric devices (TEC) in solar-assisted systems had an acceptable performance with maximum values of coefficient of performance (COP) for the system during the hottest day (July 30) found to be less than the value of 0.91 and for the coldest day (January 9) the COP values were over 0.7 but less than 2.33. The maximum heating generation in winter for the coldest day was 110 Wh compared to 75 Wh for the hottest day. As a result, it is concluded that there is a chance to produce an effective solution to the heating and cooling needs of buildings with the help of a solar-powered HVAC system.