In a pediatrician’s practice, there are a number of indications for the provision of procedural sedation. This chapter aims to provide a framework for procedural sedation from a pediatrician’s point of view, including understanding the practice setting, the patients, and the procedures themselves. Although written from a pediatrician’s perspective, this chapter is designed to apply to all sedation providers across all specialties. Additionally, in trying to create an approach to procedural sedation, it is equally important to consider when the risks of the sedation outweigh the benefits.