Care of hospitalized patients often requires diagnostic and therapeutic procedures. Often, these procedures are best done using sedation and analgesia. It is the responsibility of the pediatric hospitalist to either perform or arrange for these procedures. It is also the responsibility of the pediatric hospitalist to guarantee that any sedation or analgesia needed to perform these procedures is delivered in the safest and most effective way possible. Pediatric hospitalists can either arrange for appropriately trained staff to deliver sedation or obtain the necessary skills to perform the sedations themselves.