In this chapter a novel transducer principle, the so-called heat-transfer method, for biosensor applications will be discussed. Particular attention will be devoted to the historical events that led to the very first demonstration of the technology, after which the most recent technological developments in terms of MIP-based thermal sensing will be discussed. The technology is based on the simple principle of applying a temperature gradient over an MIP layer and studying the thermal transport over that receptor layer. The binding of the target to the polymeric receptors at the solid–liquid interface will block the heat flow over the layer, which will be registered by the transducer. In this way, a fast and low-cost readout technology is created that requires little instrumentation, allows for facile data interpretation, and can be operated by end-users who lack a technical background. The most important academic studies on the application of thermal MIP sensors in medical diagnostics, food safety screening, and environmental analysis will be summarized to fully demonstrate the technology’s commercial potential.