Early-stage detection and diagnosis of diseases is essential to a prompt commencement of treatment regimen, curbing the spread of the disease and the concomitant effect of improving human health. Thus, the accurate detection of disease biomarkers through the development of robust, sensitive, and selective diagnostic tools has remained cutting-edge scientific research for decades. Due to their merits of selective, stable, simple, and low preparation cost, molecularly imprinted polymers (MIPs) are increasingly becoming artificial substitutes for natural receptors in the design of state-of-the-art sensing devices. While there are different MIP preparation approaches, electrochemical synthesis presents a unique and outstanding method for chemical sensing application allowing a direct formation of the polymer on the transducer as well as simplicity in tuning the film properties thus, accelerating the trend in the design of commercial MIP-based sensors. This chapter evaluates recent achievements in the applications of electrosynthesized MIP sensors for clinical analysis of disease biomarkers, identifying major trends and highlighting interesting perspectives on the realization of commercial MIP-endowed testing devices for rapid determination of prevailing diseases.