Native Italian actress Caterina Murino boasts an experience of more than 20 years in the field of television and film production, as well as theater and special events hosting. Beginning with her participation in the Miss Italia beauty pageant in 1997, her career reveals a constant tension between locally based works and the engagement in multilingual projects—occasionally global hits—across all continents. Such an (ostentatious) versatility has led Murino to a unique positioning within the national star system, even at the expense of minor exposure to the Italian small screen, which somehow became her personal way to success. Thanks also to an original interview, this chapter profiles and reconstructs the actorial background of Murino, her polyhedric professional trajectories, and her multiple relationships with media, focusing on the various geographic levels implied.