Atopic dermatitisAtopic dermatitis (AD) is an inflammatory skinSkin disorder characterized by periods of chronic skin flares. Currently available treatmentTreatment options include topical therapies, phototherapy, and immunosuppressants, but these therapeutics have undesired side effects and the variability in patient presentation requires individualized treatment plans. BiomarkersBiomarkers have a large role in many fields of medicine and could potentially assess limitations in disease diagnosisDiagnosis, prognosis, and management of AD. This chapter focused on analyzing the biomarkers most closely associated with clinical outcomes in AD patients. We conducted a literature review of twelve biomarkers and used classification standards provided by the World Health Organization. Through our review we found that there are measurable levels of cytokinesCytokines, antibodies, and proteins that are associated with AD diagnosis, prognosis, and responses to treatmentTreatment. While there are biomarkers being investigated for their use in AD management, the benefit for such laboratory medicine in a historically clinically diagnosed disease is not known.