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Hypereosinophilic syndrome (HES) is a heterogeneous group of diseases characterized by peripheral eosinophilia (defined as >1.5 × 109/L) and/or tissue eosinophilia and with signs of tissue damage related to the excessive eosinophils. Skin rash is present at the disease onset in up to 25% of patients. Lymphocyte variant HES (L-HES) is associated with the highest risk of skin involvement. HES may be very difficult to differentiate from secondary hypereosinophilia and patients are best managed in a multidisciplinary team.

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Hypereosinophilic Syndrome

  • 章节

  • 发表日期：

    2025年

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  • Robert Gniadecki,
  • Minakshi Taparia,
  • Jean Deschenes,
  • Jori Hardin,
  • Etienne Mahe

摘要

Hypereosinophilic syndrome (HES) is a heterogeneous group of diseases characterized by peripheral eosinophilia (defined as >1.5 × 109/L) and/or tissue eosinophilia and with signs of tissue damage related to the excessive eosinophils. Skin rash is present at the disease onset in up to 25% of patients. Lymphocyte variant HES (L-HES) is associated with the highest risk of skin involvement. HES may be very difficult to differentiate from secondary hypereosinophilia and patients are best managed in a multidisciplinary team.