SweetpotatoSweet potato plays significant roles in the food supply worldwide. Conventional sweetpotato breeding methods face challenges such as self- and cross-incompatibility and high heterogeneity. Gene editingGene editing is an effective and powerful tool for modifying agronomic traits, offering a novel approach to develop cultivars by targeting specific genes for precise modifications. The transformed CRISPR/Cas can be segregated out from the gene-edited end product of sexually propagated crops but not in sweetpotato as sweetpotato is highly heterogeneous and has to be propagated clonally. Thus, innovative sweetpotato breeding methods need to be further developed to improve breeding efficacy and decrease breeding cycle. In the present book chapter, we reviewed the methods used for sweetpotato breeding, the success of gene editingGene editing in sweetpotato, and the challenges and constraints and the future perspectives of sweetpotato gene editingGene editing.