With the development of genomic technology, third-generation sequencing (TGS) can rapidly provide important data for genomics research and medical services. Upon sensitivity of the biomedical data, significant scientific attention has been paid to the issues of secure communication and storage. In this chapter, we introduce and implement a consortium blockchain to facilitate and protect the integrity of the communicated data. The constructed consortium blockchain stores the signatures generated from the system as a long-term certification for identity verification and non-repudiation. The elliptic curve digital signature algorithm (ECDSA) is integrated to the system for that purpose. We employ a robust attribute-based encryption (ABE) scheme for the purposes of data confidentiality and fine-grained access control. Tamper resistance is also achieved in our proposed work. A gateway is included to facilitate and provide a more efficient communication between the sequencer and main server. It also plays the role of a security node in the proposed system.