Panenteric capsule endoscopy is a novel method of assessing the gastrointestinal (GI) tract from the mouth to the anus. This has been made possible through technological advancements of having two cameras on a capsule with a wide-angle view, an adaptive frame rate, and better battery life. Specific bowel preparation with specific instructions needs to be administered. In this chapter, we review the type of bowel preparation instructions that need to be administered together with the clinical indications, these being mainly inflammatory bowel disease and GI bleeding. The limitations of this test are also reviewed as though the potential for a panenteric assessment is available, and one has to be careful on its use due to the current concerns of esophageal, gastric, and colonic mucosa visualization.