Severe small bowel (SB) dysmotility is often characterized by chronic disabling gastrointestinal (GI) symptoms, associated with dilation of some part of the SB and often inconclusive results of routine endoscopic and radiological investigations or even surgical exploration. Researchers have shown real interest in the last 15 years in the investigation of GI symptoms related to motility abnormalities with wireless capsules. In this chapter, major contributions in this field are introduced and summarized. The main aim is to show first how Computer Vision technics and Artificial Intelligence algorithms can enhance the analysis of the sequences of images extracted from a wireless capsule endoscopy examination for motility analysis, and second, to introduce recent ad hoc capsule technologies making it possible for 3D characterization of the intestinal tract motility.