Scholarlink

Gastric cancer is a worldwide disease for which several risk factors are involved. Helicobacter pylori (H. pylori) infection is considered the main micro-organism impacting carcinogenesis. One of the new scientific approaches in gastric microbiome studies is the 16S ribosomal RNA (16S rRNA) amplification by liquid biopsies with next-generation sequencing (NGS) techniques. This study is a metagenomic meta-analytic investigation based on genomic data uploaded in online medical databases. These works were selected on the basis of the amplification of the 16S rRNA gene regions of the microbiomes in gastric biopsies aiming to describe the microbial taxonomy of the patients with Helicobacter pylori infections, distinguishing relative abundance in patients. Subgroups were differentiated according to pathological diagnosis, the molecular techniques used, the study design, and the geographical origin of the individuals.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Meta-analytic Metagenomic Analysis of the Microbiome in Gastric Cancer

  • 会议论文

  • 发表日期：

    2025年

查看全文
  • Gloria Santoro,
  • Elena Locatelli,
  • Flavio Tirelli,
  • Annamaria Agnes,
  • Domenico D’Ugo,
  • Roberto Persiani,
  • Alberto Biondi,
  • Laura Lorenzon

摘要

Gastric cancer is a worldwide disease for which several risk factors are involved. Helicobacter pylori (H. pylori) infection is considered the main micro-organism impacting carcinogenesis. One of the new scientific approaches in gastric microbiome studies is the 16S ribosomal RNA (16S rRNA) amplification by liquid biopsies with next-generation sequencing (NGS) techniques. This study is a metagenomic meta-analytic investigation based on genomic data uploaded in online medical databases. These works were selected on the basis of the amplification of the 16S rRNA gene regions of the microbiomes in gastric biopsies aiming to describe the microbial taxonomy of the patients with Helicobacter pylori infections, distinguishing relative abundance in patients. Subgroups were differentiated according to pathological diagnosis, the molecular techniques used, the study design, and the geographical origin of the individuals.