Recent studies found a clear North-South hierarchy of urban areas in Europe within the context of growing multiculturalism and socioeconomic inequality. The objectives of this article are three-fold. The first is the identification of hotspots of spatial inequalities after assessing multiple socioeconomic distress. The second is to examine the spatial distribution of non-national population through their overrepresentation respect to Italian nationals. The last is to measure the local spatial correlation between the degree of potential socioeconomic distress and the concentration of the non-nationals’ population.