In this chapter, the management of maize plants for food sovereignty is explored in two specific places: Cherán K’eri, in the P’urhépecha region of Mexico, and Gera, a Saraguro community located in the southern Andean Sierra of Ecuador. Maize plays a central role in the diet and identity of the people in both areas and influences the conformation of a complex network of relationships with other species. Using a multispecies ethnographic approach, the differences in the management of maize during sowing, harvesting, and human nutrition are compared based on management practices and general interactions between people and plants and animals. Personal narratives are incorporated to provide a deeper understanding of the interactions in each location, based on personal experiences of maize cultivation. The main idea of this chapter is to consider how food sovereignty is shaped by the relationships that plants have with other species in specific contexts. It emphasizes the need to challenge anthropocentrism and promote comprehensive visions of managing and relating to plants, animals, and ecosystems when thinking about food sovereignty.