The high level of clinical interest in androgenetic alopecia (AGA) is explained by its prevalence in both men and women. The active search for possible cofactors in the complex etiology of AGA adds to our understanding of the nosology and opens new therapeutic targets that contribute to the evolution of therapy. Genetic polymorphism and pathogenetic multifactoriality observed in AGA are manifested by a variety of clinical forms of the disease. There are observations of a correlation between the age-related manifestation of AGA, gender, comorbidity, with clinical subtype, prognosis, and response to therapy, justifying a differential approach to therapy [1]. AGA, although widely common, not life threatening or painful, is a source of stress. Published reports suggest a significant negative correlation between male and female AGA and QoL, often secondary to very serious psychological problems. This chapter is dedicated to finding a personalized approach based on gender, age, clinical form and severity, as well as somatic comorbid pathology and psychostatus of patient.