This chapter introduces the notion of creative disruption as psychosocial praxis. In its transdisciplinary troubling of the received notions of an internal psyche and an external social, creative disruption is implicitly foundational to psychosocial studies. This foundation situates psychosocial studies as a particularly fertile ground from which to attend to the planned and unplanned disruption that frequently erupts throughout the terrain of the social. Seeking to challenge the Western academe’s historical regulation of epistemic disruption, the chapter introduces the question that frames this collection: how might the disruption we encounter open up junctures for creative and ethical psychosocial engagement? Further, how might disruption be harnessed and refigured as psychosocial praxis? Doing the work of creative disruption—as creatively and ethically responding to disruption—is a commitment that should be taken up widely by psychosocial thinkers and practitioners.