This study aimed at exploring nurses’ and physicians’ experiences of building health literacy in the myocardial infarction pathway. A qualitative design was applied. Nurses participated in focus groups (n = 22) and physicians were individually interviewed (n = 9). The results are presented following the different phases of the myocardial infarction pathway with three distinct themes: precise and clear information (acute phase), starting to build health literacy (hospitalisation and discharge phase), and health-literate patients (rehabilitation phase). The findings showed that building health literacy varied depending on the different phases. The study revealed weaknesses in individual and organisational health literacy that require improvement. Health professionals participating in the study were concerned with preventing risk factors and promoting a healthy lifestyle. Cooperation between health professionals and organisations involved in the pathway must be improved to strengthen continuity in building health-literate patients. Promoting health literacy from a life span perspective is important for achieving Sustainability Development Goal 3: Good health and well-being, especially target 3.4, to reduce mortality from non-communicable diseases.