CERN is operating the world’s largest particle accelerator complex in the world. The interconnection of versatile particle accelerators working with different particle beams at different intensities and energies continue to attract scientists and engineers from all over the world. The socio-economic effects generated by the presence of in the region are manifold. They include, but are not limited to consumer spending, real-estate investments and local business and services activities, investments in education, leisure activities and tourism, urban development and tax contributions. This chapter traces different local socio-economic effects of concentrating a large number of people around a research infrastructure.