The fast development of “new space” industry has in the last years given birth to new ideas not anymore only addressed to satellite needs but for the development of operations in Low Earth Orbit (LEO) to support research and development (R&D) and commercial possibilities for pharmaceutical, technological, and manufacturing firms and research institutes. This element, coupled with the extensive background and experience gained thanks to the technical and technological advances of such payload operations conducted with the ISS, now constitutes a solid knowledge base to allow LEO to become a sustainable marketplace. However, the ISS is only one platform and one that was never intended for commercial operations and manufacturing. Introducing Europe’s transportation and in orbit servicing Space Rider System (SRS) aims to respond to the above instances with a flight cadence that supports scalable manufacturing, which is the primary driver of a commercialised LEO marketplace. SRS is a new platform that offers multi-purpose service mission management, supporting a wide range of payload needs at affordable prices. SRS’s flexible model makes LEO much more accessible to the non-traditional space industries, especially those needing return capability. The SPACE RIDER long-term objective is to define and develop an affordable reusable European space transportation system able to perform experimentation and demonstration of multiple future application missions in low Earth orbit, benefiting to the maximum extent possible from existing launchers technologies, and addressing where relevant progressive technological challenges with limited risks and minimal financial efforts for Europe. The system shall be able to implement a commercially viable, sustainable, and scalable business case; as such, the system shall demonstrate to be commercially self-sustained in the long-term perspective. Enabling elements to reach this goal are linked with the two major technical challenges SRS Project is facing: demonstration of Reusability of the vehicle and of the whole system architecture of the Project and definition of a commercial case based on projected next future market development in microgravity. According to these mission goals, the first Payload Aggregate for Space Rider Maiden Flight is in preparation at ESA with commercial and institutional customers. As a central part of ongoing activities devoted to the development of a business model able to express the potential of Space Rider as a new commercial tool, in partnership among ESA, Space Commerce Matters and STAM companies has been initiated.