The school nurse’s role in supporting students with special educational needs is multifaceted and indispensable in fostering their overall well-being and academic success. This chapter explores the critical functions fulfilled by school nurses in catering to the unique healthcare needs of students with special educational needs. The school nurse serves as a liaison between healthcare providers, educators, and families, facilitating effective communication and collaboration to ensure holistic care for students with healthcare needs. By understanding each student’s medical history, disabilities, and individualized education programs, the nurse can tailor health interventions and accommodations to meet their specific needs. This chapter will explore a variety of pediatric physical and developmental diagnoses and how the school nurse can support these children, their parents, and their teachers. This chapter is designed to bridge the gap between the medical and educational spheres, offering insights into how nurses contribute to the overall well-being and success of students with special needs. We will explore the various dimensions of their role, from addressing physical health needs to providing emotional or mental health support and collaborating with educators and the community to create tailored plans for individualized care.