Opioid Use Disorder (OUD) is a chronic, relapsing condition that poses significant health, social, and economic challenges. Effective management includes pharmacotherapy, behavioral therapy, and social support. Medication-assisted treatment (MAT) with methadone, buprenorphine, and naltrexone is crucial in the management of OUD as these medications can reduce withdrawal symptoms, curb cravings, and reduce the risk of overdose. Naloxone is another critical agent in the management of OUD as it quickly reverses opioids in cases of overdose. These medications, along with many others that manage symptoms of opioid withdrawal, play a vital role in the management of OUD.